Micromonas pusilla Virus: the Virus Growth Cycle and Associated Physiological Events Within the Host Cells; Host Range Mutation

Broadbean wilt virus - identification,host range and distribution in the fars province of iran

Center manifold analysis and Hopf bifurcation of within-host virus model

A mathematical model of a within-host viral infection is presented. A local stability analysis of the model is conducted in two ways. At first, the basic reproduction number of the system is calculated. It is shown that when the reproduction number falls below unity, the disease free equilibrium (DFE) is globally asymptotically stable, and when it exceeds unity, the DFE is unstable and there ex...

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

The recent outbreak of coronavirus infectious disease 2019 (COVID- 19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. Scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARSCoV) at the genomic and transcriptomic level. Simila...

Variation in RNA Virus Mutation Rates across Host Cells

It is well established that RNA viruses exhibit higher rates of spontaneous mutation than DNA viruses and microorganisms. However, their mutation rates vary amply, from 10(-6) to 10(-4) substitutions per nucleotide per round of copying (s/n/r) and the causes of this variability remain poorly understood. In addition to differences in intrinsic fidelity or error correction capability, viral mutat...

Host range mutants of polyoma virus.

A line of polyoma-transformed mouse cells has been isolated which is fully susceptible to lytic infection by polyoma virus. This line has been used to select virus mutants which have lost most or all of their ability to grow in the untransformed parental line while retaining the ability to grow in the transformed derivative. These virus mutants are also defective in their ability to transform c...